Genetic Mod 3

Genetic Modification of Organisms for Human Consumption Part 3

Some of you may have noticed that after writing Genetic Modification of Organisms for Human Consumption parts 1 & 2 , part 3 of the series never appeared until now. I had planned to address the biggest myths from GMO supporters and opponents. However as I missed deadline after deadline wading through a minefield of confusion and illusion in the hopes of identifying fact and fiction it became clear I would be defending an industry with a less than stellar track record. For example, when I read GMO’s are a “Major threat to human fertility and very existence of human life on earth” (1) by people who reject GMO science from same organizations whose science they embrace in the debate on climate change, I expect significant data to refute organizations like the United States National Academy Sciences state: “To date, no adverse health effects attributed to genetic engineering have been documented in the human population.” But it isn’t available. In fact, one of the two most quoted papers by GMO opponents should have never made it through peer review to publication (my opinion) but, once published (2) it should have never been retracted either (my opinion again). The big splash it made when it was released became a much bigger splash when it was retracted. In turn, conspiracy theories exploded and remain even though it was republished (3). The other paper used as ‘proof’ of GMO danger is a host of unproven suppositions and creative extrapolations. (4) I read and re-read the paper and their definition of explaining disease in the modern world did not approach what I would describe as adequate, let alone confirmatory. Of course the opponents join the food fight (pun intended). I read one review (5) that wasted time attacking the authors credentials and dismissing Leaky Gut Syndrome rather than addressing the hyperbole it contained such as “glyphosphate is the most biologically disruptive chemical in our environment” and it can explain diseases in the modern world such as “inflammatory bowel disease, obesity, depression, ADHD, autism, Alzheimer’s disease, Parkinson’s disease, ALS, multiple sclerosis, cancer, cachexia, infertility, and developmental malformations.”

As I said in part 1, I do not care what the truth is as long as I know it. Modification of specific genes has a tremendous upside and a potentially dangerous downside. However, mankind has been modifying genes in crops (and animals) for thousands of years, so living with the potential for a negative outcome is nothing new. The only difference is that with transgenesis, cisgenesis and intragenesis is that we know the specific gene we modify. The main argument against GMO (specifically transgenesis) is, for example, DNA from a strawberry and a worm could never happen in nature. However, nature doesn’t graft a branch from one plant to another either. And it does not address other types of specific genetic modification {see Box 1 Three Kinds of GMO} all of which leads me to how this series started. I was curious. I have no dog in this fight and really did expect to find a lot more dishonesty from the giant agribusiness corporations than just lies about food prices rising $500 per family if GMO label laws passed. (It really surprised me that voters in California and Washington state believed them -- after all, anyone who shops for food knows that companies change their product labels all of the time! ) That being said, after spending way too much time wading through minutiae from the opponents, I have concluded the small percentage of the public who fear GMO in a disproportional manner have contributed to what has become an almost comical situation. Here are some examples:

1. Recently premium ice cream and frozen yogurt company announced their goal of becoming GMO free. This will involve scores of ingredient changes across a product line that features dozens of flavors. Eventually, they will be able to tell their customers that they are GMO free. Lost in the debate is that when folks decide to have ice cream, they don’t do so or health reasons. I doubt if they’re concerned about whether the sugar they enjoy came from a sugar beet seed that was modified transgenically or a sugar beet seed that was modified by gamma radiation. In fact, sugar beets themselves never existed in the wild. They are the result of years of modification through breeding of common table beets that would have never occurred naturally. 300 years ago a scientist discovered sucrose in the roots of common table beets. It wasn’t a lot (less than 5% vs. 20% in sugar beets grown today) but it was sugar.(6) [ At that time, all sugar came from sugar cane which only grows well in the tropics. Supply interruptions due to both weather and wars prompted a search for another source of sugar.]

2. Before agribusiness began to alter specific genes transgenically, in order to trigger a mutation they would use some form of radiation ( X-rays or gamma rays or fast neutrons) or chemicals (such as nitroso-N-methylurea which Wikipedia describes as “a highly reliable carcinogen, mutagen and teratogen” (7) on seeds and pollen to break chromosome strands and alter DNA . When that happens, the recipe to make proteins becomes altered and the result is a defective or mutated seed they hope will carry improved traits. The process is trial and error and it doesn’t take a rocket scientist to figure out most of what they burn and poison is not improved. When changes present after the ‘best” altered seeds are grown (they don’t try to grow the ‘Frankenseeds’) we have no idea the number of genes involved, what genes were mutated, where they are located and what area(s) on the genes modification occurred. And unlike the seeds that are altered specifically via transgenesis, DNA mutations with radiation and chemicals are unregulated. They do not have to undergo animal testing. They do not have to meet any environmental standards. And, if you ask experts in the field which process has a higher risk for creating something toxic, the unregulated process gets the nod.(8)

3. A top selling organic rice in California (known as Calrose 76) can be traced back to seeds that underwent gamma radiation which resulted in a shorter mutant grain that tended to stick together and retain flavor when cooked. (9) Although large corporations such as Monsanto, BASF, DuPont and other companies who are involved in agribusiness would prefer to use precise GMO techniques to create mutations with desired traits, the backlash has resulted in them returning to using unregulated radiation and poison to randomly induce mutations. (10) Please note: the rice seeds that were genetically modified with radiation 3 decades ago did not produce radioactive crops. And it doesn’t bother me that it can be called organic (if they grow it that way). What I find highly ironic is in today's topsy-turvy environment, if that rice had been altered transgenically and it was grown organically, it could not be called organic even though knowing what gene we alter carries less risk than having no idea how many genes we alter.

THE REAL PROBLEM
Nathanael Johnson, writing for GRIST quoted Dan Charles the food & agriculture correspondent for NPR, “The dispute over genetic engineering involves facts, to be sure,” he wrote. “But its parties disagree far more passionately over the story. They quarrel over the nature of the characters, the plot, and over the editing. They also feud over the unknowable: the ending.”
A genetically modified organism (GMO, also called “genetically engineered”) is a plant, animal or microorganism that contains genetic material from a source or species that could not occur naturally. For example, the Arctic Flounder lives where other fish can freeze to death. It’s ‘anti-freeze” gene has been inserted into strawberries to produce a variety that can withstand freezing temperatures. Now, I am guessing most people who read this article would not consider a strawberry like that dangerous – even if it’s blue. But this is not how the GMO controversy began. It started when companies who used to make things like DDT and Agent Orange began to insert genetic material into the seeds they sell to farmers so bug poison and weed poison they also sell to farmers can be used on the crops without killing them. When 53 people died in Germany from eating organic sprouts in 2011 they thought they had bought safer food — which leads to another overlooked aspect of the GMO safety debate: context.

CONTEXT
Eating food carries a health risk mankind has been dealing with since day 1. Every year people die from eating poison food We do not want to eat food that is full of pesticides and/or herbicides. We do not want to to consume food that is infested with insect eggs, rodent droppings, parasites, mold, fungus, bacteria or viruses. We do not want to get sick from rot, rancidity or decomposition in food---or any of the hundreds of substances we add to preserve our food and make it easier to prepare. If the DNA in a seed leads to a plant that will make us ill, we don’t want to eat it whether the DNA was altered with natural material of a different species or by an unnatural chemical. We don’t many types of natural processes that can damage what we ingest. Which leads me to another important point: everything natural is NOT healthier than everything artificial. In fact, how we define natural needs some context because most of the food crops we grow have been so artificially altered for so many years they can only survive with human assistance. Or to look at it another way: I don’t like the idea of my salad getting zapped by some sort of ray, but if that had been done to the sprouts in Germany, the E coli would have been killed and the 53 people who died would be alive to worry about the radiated food they ate that day. Something else to think about is this: if all GMO’s were banned tomorrow, farmers will still use weed killer and bug spray. The question I can’t yet answer is if we’re better off using less herbicide and more pesticide like we did before GMO crops or more herbicide and less pesticide we use with GMO crops. In closing, I believe it’s wise to watch these companies very carefully. But it is unwise to place all GMO products and promise in one sinking boat or try to use one set of rules for what should clearly be a case by case approach. After all if someone could insert DNA from a virus into peanuts and wipe out all death from peanut anaphylaxis (unless an allergic person had an organic peanut by accident) banning that procedure because you oppose inserting a different virus into a peanut so weed or bug poison won’t kill it makes no sense.

Box 1
Three Types of Genetic Modification
Transgenesis - genetic material from one organism is placed in a different organism that it cannot breed with.
Cisgenesis - genetic material from one organism is placed in a compatible organism using natural combinations of natural genes in their natural sequence.
Intragenesis - genetic material from one organism is placed in a compatible organism using natural genes in combinations and/or sequences that do not occur naturally.

1. http://articles.mercola.com/sites/articles/archive/2008/12/06/major-threat-to-human-fertility-and-very-existence-of-human-life-on-earth.aspx

2.Gilles-Eric Séralinia, Emilie Claira, Robin Mesnagea et. Al. Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food and Chemical Toxicology Volume 50, Issue 11, November 2012, Pages 4221–4231

3.Gilles-Eric Séralinia, Emilie Claira, Robin Mesnagea et. Al. Republished study: long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Environmental Sciences Europe. 2014, 26:14 doi:10.1186/s12302-014-0014-5

4. Samsel A, Seneff S. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. Entropy 2013, 15(4), 1416-1463; doi:10.3390/e15041416

5. http://www.examiner.com/article/bogus-paper-on-roundup-saturates-the-internet

6. http://cropwatch.unl.edu/sugarbeets/sugarbeet_history

7. http://en.wikipedia.org/wiki/N-Nitroso-N-methylurea

8. Committee on Identifying and Assessing Unintended Effects of Genetically Engineered Foods on Human Health, Board on Life Sciences, Food and Nutrition Board, Board on Agriculture and Natural Resources Safety of Genetically Engineered Foods Approaches to Assessing Unintended Health Effects. Institute of Medicine and National Research Council of the National Academies. The National Academies Press 2004. Washington D.C.

9. Tabastum A, Ali Cheema A, Hameed A, et al. Radio sensitivity of rice genotypes to gamma radiations based on seedling traits and physiological indices. Pakistan Journal of Botany; v. 43(2); ISSN 0556-3321; Apr 2011; p. 1211-1222

10. Kaskey J. The Scariest Veggies of Them All. Businessweek. November 21, 2013.

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